Role in Tumor Cell Survival

Role of EGFR in healthy cells in metastatic non-small cell lung cancer (NSCLC)
Role of EGFR in healthy cells in metastatic non-small cell lung cancer (NSCLC)

EGFR is a cell membrane receptor1

 

In healthy cells, EGFR plays an integral role in multiple biological processes, including proliferation, gene expression, survival, and apoptosis.1

EGFR mutations may lead to increased signaling in metastatic non-small cell lung cancer (NSCLC)
EGFR mutations may lead to increased signaling in metastatic non-small cell lung cancer (NSCLC)

At diagnosis: sensitizing EGFR mutations

Mutations in EGFR may lead to increased signaling1,2

 

EGFR activity may be dysregulated though various mechanisms, including sensitizing mutations that affect tyrosine kinase activity and lead to constitutive activation.1,2

Inhibiting EGFR may slow tumor growth in metastatic non-small cell lung cancer (NSCLC)
Inhibiting EGFR may slow tumor growth in metastatic non-small cell lung cancer (NSCLC)

Targeted therapies can inhibit EGFR signaling1

 

Inhibiting EGFR may slow tumor cell growth.1

EGFR, epidermal growth factor receptor; NSCLC, non–small cell lung cancer; TKI, tyrosine kinase inhibitor.

References: 1. Baselga J. Oncologist. 2002;7(suppl 4):2-8. 2. Sharma SV et al. Nat Rev Cancer. 2007;7(3):169-181.