Role in Tumor Cell Survival

Role of PD-L1 in healthy cells
Role of PD-L1 in healthy cells

PD-L1 regulates T-cell–mediated immunity1,2 

 

PD-L1 is expressed on the surface of various immune cells. Binding of PD-L1 to PD-1 inhibits T-cell activity and protects normal tissue from autoimmune responses.1-3

Upregulation of PD-L1 can allow for tumor growth in urothelial carcinoma
Upregulation of PD-L1 can allow for tumor growth in urothelial carcinoma

Some tumor cells upregulate PD-L1 to evade the antitumor response1,4

 

Binding of PD-L1 to PD-1 receptors inactivates T cells, which suppresses immune surveillance and allows for tumor growth.1

Inhibiting the PD-1/PD-L1 pathway can slow tumor growth in urothelial carcinoma
Inhibiting the PD-1/PD-L1 pathway can slow tumor growth in urothelial carcinoma

Blocking PD-L1 may promote the antitumor response3-5

 

Immunotherapy uses checkpoint inhibitors to block the interaction of PD-L1 and PD-1, which may allow for reactivation of T cells and promote the antitumor response.3-5

 

 

PD-1, programmed cell death protein 1; PD-L1, programmed death-ligand 1.

 

References: 1. Pardoll DM. Nat Rev Cancer. 2012;12(4):252-264. 2. Sznol M, Chen L. Clin Cancer Res. 2013;19(5):1021-1034. 3. McDermott DF, Atkins MB. Cancer Med. 2013;2(5):662-673. 4. Chen DS et al. Clin Cancer Res. 2012;18(24):‍6580-6587. 5. Mellman I et al. Nature. 2011;480(7378):480-489.